Program

Sep 9, Sunday

19:30 – 21:00 – Welcome dinner reception in the Education Center

21.00 – 21.30 – After dinner talk: I0: Smilde A., Open issues in metabolomics data analysis

Afterwards     – Get together at „Clubraum“ of the Education Center

Sep 10, Monday

1) Morning Session: „Shiny design: What is important when designing experiments?“

08:50 – 09:00 – Opening of MOVISS: Peter Filzmoser and Tomáš Adam

09:00 – 09:40 – I1: Steffen Neumann – From profiling to biochemical insights

09:40 – 10:00 – Discussion

10:00 – 10:30 – Short Oral Presentations (No. 1 – 5)

1) Aksenov A., Molecular networking and data sharing as a gateway to new discoveries
2) Coman C., SIMPLEX: from extraction to underlying molecular mechanisms in cardiomyopathy
3) Mádrová L., Mass spectrometric analysis of purine de novo biosynthesis
4) Tengölics R., Method development for non-targeted metabolite profiling of yeast using FIA-HRMS
5) Richter C., Improving the resolution of metabolic flux analysis by tandem mass spectrometry

10:30 – 10:50 – Discussion

10:50 – 11:20 – Coffee break and poster viewing of oral presentations

11:20 – 11:50 – Short Oral Presentations  (No. 6 – 10)

6) Kouřil Š., Removing false features in metabolomics data using correlations
7) Borgsmüller N., Optimization and automation of data processing in GC-MS metabolomics for large-scale processing
8) Buescher J., Fully automated processing of LC-MS and GC-MS data
9) El Abiead Y., Should the choice of your data preprocessing tool depend on your experimental conditions?
10) Najdekr L., Wide detection coverage of the human metabolome using multiple ultra performance liquid chromatography methods – the necessity of multiple separation conditions in untargeted metabolomics experiment

11:50 – 12:10 – Discussion

12:10 – 13:00 – Discussion (data clinic)

13:00 – 14:00 – Lunch

2) Afternoon Session: „Misty mountains: How to find peaks hidden in mists? What is a real peak?“

14:00 – 14:40 – I2: Tomáš Pluskal – Reaching the summit: the importance of feature detection

14:40 – 15:00 – Discussion

15:00 – 15:30 – Short Oral Presentations  (No. 11 – 15)

11) Reichl B., Multi-omic analysis facilitates a comprehensive characterization of lipid and protein patterns in cerebrospinal fluid from medulloblastoma patients
12) Bianchi F., A metabolomic approach to evaluate the attractant and phagostimulant mechanism of different yeast species to Drosophila suzukii
13) Blackburn G., A small scale study in trained Cyclists: Can trends be used to account for biological variability and push towards individualized metabolomics in personalised medicine?
14) Junghanns S., Stationary 13C MFA with HepG2 cells
15) Love K., Rapid diagnostic approaches for thoracic disease based on pleural effusions.

15:30 – 15:50 – Discussion

15:50 – 16:20 – Coffee break and poster viewing of oral presentations

16:20 – 16:50 – Short Oral Presentations  (No. 16 – 20)

16) Narduzzi L., The CCC approach: a tool for improving confidence in natural compound identification
17) Trautwein C., Shifting, rising and shrinking peaks: Things to consider in 1H NMR-based metabolomics of blood and tissue
18) Piasecka A.,Profiling of secondary metabolites related to pattern-triggered immunity in model plant Arabidopsis and evolutionary related species
19) Kokova D., NMR-based exploratory metabolomics study of opisthorchiasis
20) Shipley P., Nuclear Magnetic Resonance Spectroscopy Paired with Chemometric Analysis for the Discrimination, Characterization, and Classification of Highly Related Medicinal Plant Samples

16:50 – 17:10 – Discussion

17:30 – 18:30 – Short walk to the restaurant

18:30 – 22:00 – Dinner

Sep 11, Tuesday

08:30 – 13:00 – Hiking

13:00 – 14:00 – Lunch 

3) Afternoon Session: „Mountain safety: awareness of strengths and weakness of statistical tools“

15:00 – 15:40 – I3: Beata Walczak – Again about data pre-processing

15:40 – 16:00 – Discussion

16:00 – 16:30 – Coffee break and poster viewing of oral presentations

16:30 – 17:10 – I4: Johan Westerhuis – Variable selection and classification in the presence of observation below the detection limit using error rate p-values

17:10 – 17:30 – Discussion

17:30 – 17:50 – Short Oral Presentations  (No. 21 – 23)

21) Kosmopoulou M., Metabolic Profiling of Human Melanoma during Metastasis
22) Panagiotakis A., Mapping the Metabolic Landscapes of Human Urothelial Bladder Carcinoma
23) Pecinova A., Tissue and plasma metabolomic analysis of DAPIT protein knockout rats – from mitochondria to glucose homeostasis

17:50 – 18:00 – Discussion

18:15 – 19:15 – Walk to the restaurant

19:30 – 22:00 – Dinner

Sep 12, Wednesday

4) Morning Session: „Home run: Results Interpretation – Be creative, critical and think next?“

09:00 – 09:40 – I5: Royston Goodacre: Mass Appeal: lessons learnt from large-scale mass spectrometry-based metabolomics

09:40 – 10:20 – Discussion

10:20 – 10:45 – Short Oral Presentations  (No. 24 – 28)

24) Rusz M., Metabolomics in preclinical studies on metal based anticancer drugs
25) Saw N., Application of generalized additive models in metabolic changes of microbial community in enhanced biological phosphate removal
26) Široká J., Effect of cyclin-dependent kinase 4/6 inhibitors on cellular metabolome regarding selectivity
27) Tripathi A., Intermittent hypoxia and hypercapnia, a hallmark of obstructive sleep apnea, alters the gut microbiome and metabolome
28) Václavík J., Acylcarnitine profile of 3-hydroxy-3-methylglutaryl CoA lyase deficiency patients

10:45 – 11:00 – Discussion

11:00 – 11:30 – Coffee break and poster viewing of oral presentations

11:30 – 12:30 – Discussion (data clinic)

12:30 – 13:00 – Closing Moviss 2018

13:00 – 14:00 – Lunch