Sep 9, Sunday
19:30 – 21:00 – Welcome dinner reception in the Education Center
21.00 – 21.30 – After dinner talk: I0: Smilde A., Open issues in metabolomics data analysis
Afterwards – Get together at „Clubraum“ of the Education Center
Sep 10, Monday
1) Morning Session: „Shiny design: What is important when designing experiments?“
08:50 – 09:00 – Opening of MOVISS: Peter Filzmoser and Tomáš Adam
09:00 – 09:40 – I1: Steffen Neumann – From profiling to biochemical insights
09:40 – 10:00 – Discussion
10:00 – 10:30 – Short Oral Presentations (No. 1 – 5)
1) Aksenov A., Molecular networking and data sharing as a gateway to new discoveries
2) Coman C., SIMPLEX: from extraction to underlying molecular mechanisms in cardiomyopathy
3) Mádrová L., Mass spectrometric analysis of purine de novo biosynthesis
4) Tengölics R., Method development for non-targeted metabolite profiling of yeast using FIA-HRMS
5) Richter C., Improving the resolution of metabolic flux analysis by tandem mass spectrometry
10:30 – 10:50 – Discussion
10:50 – 11:20 – Coffee break and poster viewing of oral presentations
11:20 – 11:50 – Short Oral Presentations (No. 6 – 10)
6) Kouřil Š., Removing false features in metabolomics data using correlations
7) Borgsmüller N., Optimization and automation of data processing in GC-MS metabolomics for large-scale processing
8) Buescher J., Fully automated processing of LC-MS and GC-MS data
9) El Abiead Y., Should the choice of your data preprocessing tool depend on your experimental conditions?
10) Najdekr L., Wide detection coverage of the human metabolome using multiple ultra performance liquid chromatography methods – the necessity of multiple separation conditions in untargeted metabolomics experiment
11:50 – 12:10 – Discussion
12:10 – 13:00 – Discussion (data clinic)
13:00 – 14:00 – Lunch
2) Afternoon Session: „Misty mountains: How to find peaks hidden in mists? What is a real peak?“
14:00 – 14:40 – I2: Tomáš Pluskal – Reaching the summit: the importance of feature detection
14:40 – 15:00 – Discussion
15:00 – 15:30 – Short Oral Presentations (No. 11 – 15)
11) Reichl B., Multi-omic analysis facilitates a comprehensive characterization of lipid and protein patterns in cerebrospinal fluid from medulloblastoma patients
12) Bianchi F., A metabolomic approach to evaluate the attractant and phagostimulant mechanism of different yeast species to Drosophila suzukii
13) Blackburn G., A small scale study in trained Cyclists: Can trends be used to account for biological variability and push towards individualized metabolomics in personalised medicine?
14) Junghanns S., Stationary 13C MFA with HepG2 cells
15) Love K., Rapid diagnostic approaches for thoracic disease based on pleural effusions.
15:30 – 15:50 – Discussion
15:50 – 16:20 – Coffee break and poster viewing of oral presentations
16:20 – 16:50 – Short Oral Presentations (No. 16 – 20)
16) Narduzzi L., The CCC approach: a tool for improving confidence in natural compound identification
17) Trautwein C., Shifting, rising and shrinking peaks: Things to consider in 1H NMR-based metabolomics of blood and tissue
18) Piasecka A.,Profiling of secondary metabolites related to pattern-triggered immunity in model plant Arabidopsis and evolutionary related species
19) Kokova D., NMR-based exploratory metabolomics study of opisthorchiasis
20) Shipley P., Nuclear Magnetic Resonance Spectroscopy Paired with Chemometric Analysis for the Discrimination, Characterization, and Classification of Highly Related Medicinal Plant Samples
16:50 – 17:10 – Discussion
17:30 – 18:30 – Short walk to the restaurant
18:30 – 22:00 – Dinner
Sep 11, Tuesday
08:30 – 13:00 – Hiking
13:00 – 14:00 – Lunch
3) Afternoon Session: „Mountain safety: awareness of strengths and weakness of statistical tools“
15:00 – 15:40 – I3: Beata Walczak – Again about data pre-processing
15:40 – 16:00 – Discussion
16:00 – 16:30 – Coffee break and poster viewing of oral presentations
16:30 – 17:10 – I4: Johan Westerhuis – Variable selection and classification in the presence of observation below the detection limit using error rate p-values
17:10 – 17:30 – Discussion
17:30 – 17:50 – Short Oral Presentations (No. 21 – 23)
21) Kosmopoulou M., Metabolic Profiling of Human Melanoma during Metastasis
22) Panagiotakis A., Mapping the Metabolic Landscapes of Human Urothelial Bladder Carcinoma
23) Pecinova A., Tissue and plasma metabolomic analysis of DAPIT protein knockout rats – from mitochondria to glucose homeostasis
17:50 – 18:00 – Discussion
18:15 – 19:15 – Walk to the restaurant
19:30 – 22:00 – Dinner
Sep 12, Wednesday
4) Morning Session: „Home run: Results Interpretation – Be creative, critical and think next?“
09:00 – 09:40 – I5: Royston Goodacre: Mass Appeal: lessons learnt from large-scale mass spectrometry-based metabolomics
09:40 – 10:20 – Discussion
10:20 – 10:45 – Short Oral Presentations (No. 24 – 28)
24) Rusz M., Metabolomics in preclinical studies on metal based anticancer drugs
25) Saw N., Application of generalized additive models in metabolic changes of microbial community in enhanced biological phosphate removal
26) Široká J., Effect of cyclin-dependent kinase 4/6 inhibitors on cellular metabolome regarding selectivity
27) Tripathi A., Intermittent hypoxia and hypercapnia, a hallmark of obstructive sleep apnea, alters the gut microbiome and metabolome
28) Václavík J., Acylcarnitine profile of 3-hydroxy-3-methylglutaryl CoA lyase deficiency patients
10:45 – 11:00 – Discussion
11:00 – 11:30 – Coffee break and poster viewing of oral presentations
11:30 – 12:30 – Discussion (data clinic)
12:30 – 13:00 – Closing Moviss 2018
13:00 – 14:00 – Lunch